Keep junk buff in first two or three slots. Once you get your truly beneficial buffs click the junk buffs off, go fight. If you manage to get some nasty spells(Malos/Tash come to mind)they will land in slots one or two. Instead of taking up your cleric or shammys spell slots for cure disease just switch your off hand weap with this and wait for a proc or two. If you did it right the malos or tash should go away. BTW this is only something I thought of, I will test it out on my warrior to see if it is useful for that.
-Itching Go'Squishy
65 War Emarr.