I got my alchemy skill to 300 before I did the trophy quest. But it was so easy to do, just tedious grabbing all the components for combines involved with the quest. I needed one of these for a turn in to get Master Trophy, otherwise it's a waist of time, because the Master Trophy soon evolved to it's 7/7 which is called Mundunugu Medicine Stick giving 15% mod to alchemy and summoned a Master carry all which does the same as the grandmaster's satchel. so this one is a waist of time.
Tip: My alchemy was at 210 (no trophy, or mod) I started buying Nodding Blue Lily's in baz for 20p each (went through 1200+ of them). But if you make Alacrity X potions with them (yield 5) with other components, even with the success/failure ratio, you sell the potions to merchant and break even, while taking your skill all the way to 300. The potions are trivial 348.
My master trophy was 12% mod which gave me skill of 336, I continued making the alacrity 10 potions and my trophy evolved :)