Make Poison, or poison crafting, is a tradeskill reserved to the rogue class. Rogues are able to combine a number of ingredients, many of which are also used in alchemy, to affect mobs in a number of ways. Rogues may create snare, direct-damage, death-over-time, or attack-slowing poisons.
Rogues also receive the skill Apply Poison. As this skill improves, the rate of successfully applying the poison to the primary weapon will increase.